Czech Society for Structural Biology
Česká společnost pro strukturní biologii

The Czech Society
for Structural Biology
(Česká společnost
pro strukturní biologii

Videnska 1083
CZ-142 20 Prague
Czech Republic
VAT number: 0022869433
account num.: 2300076583/2010
IBAN: CZ2820100000002300076583

Czech Society for Structural Biology
Institute of Biotechnology AS CR
Czech and Slovak Crystallographic Association and
Institute of Physical Biology, University of Southern Bohemia, Ceske Budejovice


IX Discussions in Structural Molecular Biology

Nové Hrady, March 24 - 26 2011

Abstracts of the talks and posters

Participants of IX Discussions



Thursday, March 24

12:00 - 13:15 Registration

13:30 - 13:45 Opening

13:45 - 15:45 Session I, chairperson Vladimír Sklenár

I. Barák: Lipid helices formation in Bacillus subtilis cell membrane (*)

P. Dvorák: Engineering of biochemical pathway for degradation of Anthropogenic environmental pollutant 1,2,3-trichloropropane

J. Prchal: Expression and purification of myristoylated matrix protein of Mason-Pfizer monkey virus for Structural Studies

J. Dohnálek: The molecular puzzle of C-type lectin like natural killer cell receptors

P. Malý: Generation of artifical binders with affinity to human cytokines via computer-assisted mutagenesis of a stable protein scaffold and ribosome display selection (*)

15:45 - 16:00 Coffee break

16:00 - 18:00 Session II, chairperson Petr Novák

D. Rozbeský: Chemical cross-linking and H/D exchange combined with mass spectrometry: A tool to validate and refine 3-D protein X–ray model

P. Hanc: Structural details of NKR-P1D: Clrb interaction elucidated by protein cross-linking and mass spectrometry

V. Andrushchenko: Supramolecular Assemblies Formed by Diolein and Stearyl Alcohol

L. Rezábková: Structure of the 14-3-3/RGS3 complex: New details on architecture of complexes formed by 14-3-3 proteins

M. Šebela: Structural and functional study on the glycosylation in maize cytokinin oxidase/dehydrogenase1

P. Man: Accessibility changes within diphtheria toxin T domain upon membrane penetration probed by hydrogen exchange and mass spectrometry

18:30 - 20:00 Opening dinner, at the Novy Zamek

20:00 - 22:00 Poster session I, at the Novy Zamek

Friday, March 25

7:00 - 8:45 Breakfast

9:00 - 10:30 Lecture Session III, chairperson Bohdan Schneider

Z. Chval: Mechanism of the Oxaliplatin Binding to the Double-Stranded 1,2-ds(pGpG) Dinucleotide in Aqueous Solution

J. Precechtelová: Torsion angle dependence of phosphorus chemcial shifts in a nucleic acid backbone from combined molecular dynamics and density functional calculations (*)

V. Sychrovský: Proposal of alternative pathway of the glycosidic bond cleavage mechanism of 8-oxoguanosine catalyzed by the human DNA repair protein hOGG1

Z. Futera: Application of New QM/MM Interface to Study of Ru Drugs Interacting with DNA

10:30 - 10:50 Coffee break

10:50 - 12:10 Session IV, chairperson Vladimir Baumruk

V. Profant: Experimental and theoretical study of formation of polyproline II helix by means of Raman optical activity

J. Hudecová: Conformational study of the cyclo(L-Trp-L-Trp)dipeptide

D. Reha: Biological Applications of QM/MM Calculations with Explicit MM Polarization

I. Kishko: Kinetic analysis of E. coli WrbA redox activity

12:15 - 13:45 Lunch

14:00 - 15:30 Lecture Session V, chairperson Petr Malý

J. Hasek: Reliability and Accuracy of Structure Determination in Diffraction Methods

P. Rezácová: Crystal structures of two protease inhibitors from tick saliva (*)

A. Štepánková: Three-dimensional structure of binunctional anhydrolase

T. Koval: Structural analysis of a recombinant plant bifunctional nuclease TBN1

15:30 - 15:50 Coffee break

15:50 - 17:30 Lecture Session VI, chairperson Jiri Vondrasek

L. Urbániková: Structural basis for substrate recognition by GH30 glucuronoxylanase from Erwinia Chrysanthemi (*)

J. Brynda: Crystal structure of the mouse galectin-4 N-terminal carbohydrate recognition domain (*)

O. Kroutil: Structure and Conformatial Behavior of the DNA Oligonucleotide Attached to the Charged Surface: A Molecular Dynamics Study

M. Krupicka: Competing reactions of disulphides and hydroxyl anion - QM study

18:00 - 19:30 Dinner

19:45 - 20:30 First General Assembly of the Czech Society for Structural Biology, at the Novy Zamek. Meeting will be held in the Czech and/or Slovak languages.

Program of the General Assembly

  • Vyrocni zprava Rady CSSB o cinnosti
  • Schvaleni vyrocni zpravy Rady CSSB o cinnosti
  • Navrh a volba revizni komise CSSB
  • Situace v evropske infrastrukture pro integrativni strukturni biologii INSTRUCT
  • Ruzne
  • Diskuze


20:45 - 23:00 Poster session II, at the Novy Zamek

Saturday, March 26

7:00 - 9:00 Breakfast

9:15 - 10:45 Session VII, chairperson Pavlina Rezacova

R. Dvorský: Impact of Point Mutations on Protein Functions: Example Case of Ras GTPases (*)

P. Pachl: Structure-based drug design of selective 5'-nucleotidases inhibitors

A. Krenek: CERIT-SC Centre: Looking for Synergies in Scientific Computing

M. Ruda: MetaCentrum in e-Infrastructure era

10:45 - 11:00 Coffee break

11:00 - 12:00 Session VIII, chairperson Richard Hrabal

O. Skrehota: QSPR modeling - algorithms, challenges and IT solutions

J. Houser: Aleuria aurantia lectin family - structural insight into differences of carbohydrate binding among related proteins

R. Ettrich: Functional coupling of DNA duplex translocation to its cleavage in a type I restriction enzyme

12:05 - 12:10 Concluding Remarks

12:15 - 14:00 Lunch


All events are held at the Rezidence hotel unless stated othewise.

Thirty minute talks are labeled by an asterix, (*), other talks have a limit of 20 minutes.

All times include discussion and will be strictly observed.


Please, send questions and comments to Bohdan Schneider

(c) Bohdan Schneider, IBT AS CR, v.v.i. 2011